WebMay 10, 2024 · Microbial secondary metabolites encoded in biosynthetic gene clusters (BGCs) are a prolific source of drugs, whereas most of these BGCs are cryptic. Thus, … WebMay 1, 2024 · Most of the biosynthetic gene clusters (BGCs) found in filamentous fungi are silent under standard laboratory cultivation conditions due to the lack of expression triggering stimuli, representing a considerable drawback in drug discovery. To access the full biosynthetic potential of these microbes, studies towards the activation of cryptic BGCs …
143 Synonyms & Antonyms of CRYPTIC - Merriam Webster
WebSep 6, 2024 · Untargeted metabolomics is used to identify BGC-specific mass features through an all-versus-all comparison. c Examples of extracted ion chromatograms (EIC) … WebMay 10, 2024 · The emergence of drug resistance highlights the importance of new drug discovery. Microbial secondary metabolites encoded in biosynthetic gene clusters (BGCs) are a prolific source of drugs, whereas most of these BGCs are cryptic. Thus, taking strategies to activate these cryptic BGCs is of great importance for potential drug … lighthouse james taylor lyrics
The histone deacetylase clr3 regulates secondary metabolite
WebJun 1, 2024 · A first challenge lies in prioritizing (cryptic) BGCs in terms of their potential for chemical novelty and/or clinical relevance to optimally exploit the wealth of available biological, genomic ... WebJan 29, 2024 · BGCs are either silent or cryptic in the original actinobacteria; hence, understanding the molecular mechanisms of BGCs is important for redesign of novel NPs (Wright 2024). Natural products have been listed in Table 8.1 that are expressed by heterologous method in a variety of hosts using multiple approaches. Webadjective Also cryp·ti·cal. mysterious in meaning; puzzling; ambiguous: a cryptic message. abrupt; terse; short: a cryptic note. secret; occult: a cryptic writing. involving or using … peachy puree