Erythroferrone function
WebHanudel et al. investigated the effects of hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHIs) on iron metabolism in a chronic kidney disease (CKD) mouse model and showed that vadadustat, an HIF-PHI, exerted beneficial effects on anemia and iron disorders independently of erythr … WebApr 8, 2024 · During experimental anemia, erythroferrone responds by increasing its expression and suppressing hepcidin production, following the pattern observed in mammals, but it is not influenced by iron overload. However, during bacterial infection, erythroferrone is downregulated and hepcidin levels increase.
Erythroferrone function
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WebSep 9, 2024 · The hormone erythroferrone (ERFE) is produced by erythroid cells in response to hemorrhage, hypoxia or other erythropoietic stimuli, and suppresses the hepatic production of the iron-regulatory hormone hepcidin, thereby mobilizing iron for erythropoiesis. Suppression of hepcidin by ERFE is thought to be mediated by … WebSep 5, 2014 · Myonectin/erythroferrone (also known as CTRP15) is a secreted hormone with metabolic function and a role in stress erythropoiesis. Despite its importance in physiologic processes, biochemical ...
WebApr 7, 2024 · Manipulation of the iron-regulatory proteins erythroferrone and erythropoietin affects glucose and lipid metabolism. Several lines of evidence suggest that iron accumulation and metabolism may ... WebJul 28, 2024 · Myonectin/erythroferrone (also known as CTRP15) is a secreted hormone with metabolic function and a role in stress erythropoiesis. Despite its importance in physiologic processes, biochemical characterization of the protein is lacking. Here, we show that multiple protein modifications are critical f …
WebOct 4, 2024 · Iron absorption is tightly regulated by erythropoietic demand via control of hepcidin expression. 1 Hepcidin inhibits the cellular iron exporter ferroportin, 2, 3 which reduces iron recycling through splenic macrophages and uptake of … WebMar 10, 2024 · Erythroferrone is produced by erythrocyte precursors (erythroblasts) in the marrow in proportion to their number and state of activation, and suppresses hepcidin …
WebJun 17, 2024 · Objective: The aim of this study was to evaluate non-transferrin-bound iron (NTBI) and labile plasma iron (LPI) levels and other parameters of iron metabolism in children undergoing therapy for acute leukemia or after hematopoietic cell transplantation (HCT), in the context of iron overload. Patients: A total number of 85 children were …
WebErythroferrone structure, function, and physiology: Iron homeostasis and beyond. Erythroferrone and hepcidin as mediators between erythropoiesis and iron metabolism during allogeneic hematopoietic stem cell transplant. Association of decreased myonectin levels with metabolic and hormonal disturbance in polycystic ovary syndrome. heated whelping box for dogsWebJun 1, 2014 · Tomas Ganz and colleagues identify a new regulator of iron metabolism, erythroferrone, that is produced by erythroblasts in response to erythropoietin and suppresses hepcidin expression during ... heated white house meetingWebNX_Q4G0M1 - ERFE - Erythroferrone - Function. Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and … move dock to another screen macWebApr 8, 2024 · The study of erythroferrone evolution and its biological role in teleost fish can give us valuably new insights into its function. To address these questions, we … heated whirlpool bathtubWebDec 28, 2024 · Erythroferrone (ERFE) is a hormone produced by erythroblasts in response to erythropoietin. ERFE acts as a regulator of hepcidin expression during stress … move docker containerWebOct 4, 2024 · When iron is required after acute blood loss or because of hypoxia, hepcidin is suppressed to allow iron mobilization for increased erythropoiesis. 4 Erythropoietin (EPO) causes hepcidin suppression, 5-7 at least in part by increasing synthesis of the hormone erythroferrone (ERFE). 8 ERFE is produced by erythroblasts after bleeding or EPO ... moved need to change addressWebOct 9, 2024 · This leads to suppression of hepcidin transcription by erythroferrone (ERFE), an EPO target gene produced by erythroblasts ( Kautz et al., 2014 ), by molecules (e.g., PDGF-BB) released by other … move docker container to another server