Fgl2 prothrombinase
WebFibrin deposition was universal in the lungs of SARS patients and fgl2 prothrombinase gene, a novel procoagulant, was demonstrated to express highly in a clinically relevant SARS model. To investigate whether and which structural protein of SARS-CoV induced transcription of hfgl2 prothrombinase gene … WebOct 13, 2024 · These observations suggest that FGL2 prothrombinase, in conjunction with thrombin and tissue factor, may contribute to tumor hypercoagulability and possibly to angiogenesis and metastasis. In turn, FGL2 may serve as a novel target for the intervention of tumor development. Nevertheless, there are no relevant literature reports on whether …
Fgl2 prothrombinase
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WebFigure 1. The last part of of KSHV gene map (From GenBank accession no. AF148805 [21]); the orientation of identified ORFs is denoted by the direction of arrows. KSHV genome encodes 86 genes, 25% of them are involved in immune system modulation. The CD200/vOX2 protein, which is encoded by ORF K14, is a bicistronic transcript which also …
WebFeb 1, 2001 · Fibinogen-like protein 2 (Fgl2) is a novel prothrombinase exhibiting coagulation activity and immunomodulatory effects. Although Fgl2 is known to play a vital role in the development of liver and interstitial fibrosis, its function in renal fibrosis remains unclear. In this study, Fgl2 expression was found to be markedly increased in kidney ... WebFeb 1, 2024 · The presentation of FGL2 varies in other organs, such as lungs, breast, and muscles. The biological functions of FGL2 protein. FGL2 gene expression is associated with pleiotropic physiologic functions, especially prothrombinase activity and immune suppression. Membrane-bound FGL2 protein shows the activity of the prothrombinase …
WebThe recent discovery of the fgl2 gene, which encodes for MHV-3-induced prothrombinase (fgl2 prothrombinase), allows for fundamental studies to determine the molecular basis for fulminant liver failure. Transcription of the fgl2 gene and translation of the protein it encodes were examined in the liver and other organs of susceptible mice ... WebMentioning: 40 - Fibrinogen-like protein 2/fibroleukin (Fgl2) plays a pivotal role in the pathogenesis of both experimental and human fulminant hepatic failure. We have reported recently that the nucleocapsid (N) protein from strains of murine hepatitis virus (MHV-3, MHV-A59), which cause massive hepatocellular necrosis but not from strains (MHV …
WebDetector: ab285145, Mouse FGL2/Prothrombinase Detector Antibody (unconjugated) The reference range value is 0.1875 - 12 ng/mL. Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.
WebDownregulation of FGL2/prothrombinase delays HCCLM6 xenograft tumour growth and decreases tumour angiogenesis Liver Int. 2012 Nov;32 (10):1585 ... FGL2 downregulation was performed by targeting microRNA in a HCCLM6 cell line in which FGL2 was highly expressed in xenografts of nude mice. The effects of FGL2 knockdown on tumour growth … hawkes lawyers buderimWebFibinogen-like protein 2 (Fgl2) is a novel prothrombinase exhibiting coagulation activity and immunomodulatory effects. Although Fgl2 is known to play a vital role in the development of liver and interstitial fibrosis, its function in renal fibrosis remains unclear. In this study, Fgl2 expression was found to be markedly increased in kidney ... boston bay smallgoods companyWebIt is postulated that FGL2 has pleiotropic effects and is an important immune regulator of both innate and adaptive responses. In macrophages and endothelial cells, FGL2 is expressed as a membrane-associated protein, which acts as a prothrombinase enzyme with the ability to generate thrombin directly from prothrombin. boston bay medical clinicWebfgl2 prothrombinase, by its ability to generate thrombin, has been shown to be pivotal to the pathogenesis of viral-induced hepatitis, cytokine-induced fetal loss syndrome, and xeno- and allograft rejection. In this study, the molecular basis of fgl2 prothrombinase activity was examined in detail. Purified fgl2 protein generated in a ... boston bay medical port lincolnWebJan 13, 2008 · As a representative proinflammatory gene, mfgl2 prothrombinase expression was evident in terminal and respiratory bronchioles, alveolar epithelia and … boston bbb complaintsWebMay 28, 2010 · Fibrinogen-like protein 2 (FGL2), which shares 36% protein homology to the fibrinogen β- and γ-chains, is a unique glycoprotein that exhibits novel prothrombinase activity when associated with cell membranes/phospholipid vesicles, depending on the serine 89 at the linear N-terminal domain [4]. boston bays roll sushiWebDetector: ab285145, Mouse FGL2/Prothrombinase Detector Antibody (unconjugated) The reference range value is 0.1875 - 12 ng/mL. Our carrier-free antibodies are typically … boston bay range hood