WebbHIPK2 has two major functions. It acts as a co-repressor for NK homeodomain transcription factors, increasing their DNA binding affinity and their repressive effect on transcription. … Webb1 apr. 2012 · Hipk promotes the stabilization of Armadillo by inhibiting its ubiquitination (and hence subsequent degradation) by the SCFSlimbE3 ubiquitin ligase complex. Vertebrate Hipk2 impedes β-catenin ubiquitination to promote its stability and the Wnt signal in a mechanism that is functionally conserved.
HIPK1 homeodomain interacting protein kinase 1 [ (human)]
WebbHIPK2 enhances expression of p53 target genes that resulting in growth arrest and the enhancement of UV-induced apoptosis that could be inhibited by antisense to HIPK2. … WebbHIPK2 is a conserved serine/threonine nuclear kinase that interacts with homeodomain transcription factors. For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization. Bioinformatics Protein Aliases: hHIPk2; Homeodomain-interacting protein kinase 2 Gene Aliases: HIPK2; PRO0593 hyoscine drooling
The nutrient sensor OGT regulates Hipk stability and tumorigenic …
Webb18 sep. 2012 · Hippo-dependent phosphorylation of Yki by Wts prevents nuclear accumulation of Yki. In the nucleus, Yki cooperates with its partner Scalloped to promote expression of several target genes that inhibit apoptosis and promote mitosis. Two studies report that the serine-threonine kinase homeodomain-interacting protein kinase (Hipk) … WebbHeLa cells were transfected with expression plasmids for wild type GFP-HIPK fusion proteins or the Tyr-Phe mutants thereof (YF). If indicated, cells were ... of wild-type … Webb13 jan. 2024 · O-GlcNAc transferase (OGT) transfers the sugar O-GlcNAc to serine and threonine residues of target proteins, a process known as O-GlcNAcylation.Using … hyoscine dry mouth